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This American Medical Association (AMA) and U.S. Public Health Service (PHS)-sponsored film aims to present the most current knowledge about causes, effects, and treatment of syphilis. Remarks by the heads of the AMA and PHS open the film, and doctors are shown lecturing and describing symptoms and indications of primary and secondary syphilis. Clinical techniques for examining patients and testing for syphilis are shown. Recommended treatments including arsenic, bismuth, and mercury for various manifestations and duration of disease are presented.